经颞浅动脉灌注PDD-Fudr/5Fu治疗头颈部鳞状细胞癌

The effect of arterial-chemotherapy in squamous cell carcinoma of head and neck

目的 观察经颞浅动脉灌注PDD +Fudr/ 5 Fu治疗头颈部鳞状细胞癌的疗效。方法 从 1996年 1月～ 2 0 0 0年 12月有 89例头颈部鳞状细胞癌给予动脉化疗 ,A组 4 9例予PDD +Fudr方案 ,B组 4 0例予PDD + 5Fu方案 ,方法与剂量两组相同。结果 A组的总有效率为 83.7% (41/ 4 9) ,其中CR10 .2 % ,PR73.5 % ,SD16 .3% ;B组的总有效率为 75 .0 % (30 / 4 0 ) ,其中CR2 .5 % ,PR72 .5 % ,SD2 5 % ,统计学上两组有效率无明显差异 (P >0 .0 5 )。而口腔溃疡在A组的发生率明显低于B组 ,经 χ2 检验 ,两组有显著差异。结论Fudr在头颈部鳞状细胞癌的辅助化疗中是安全、低毒、高效的 ,值得推荐。

Objective To evaluate the effect of arterial\|chemotherapy of Fudr in squamous cell carcinoma of head and neck as neoadjuvant chemotherapy. Methods From 1996. Jan. to 2000.Dec. there were 89 patients with squamous cell carcinoma of head and neck were treated with arterial\|chemotherapy of Fudr or 5\|Fu plus PDD plan, the rate of effect and side\|effect were evaluated.Results The total response rate is not different between the two groups, and there is less side\|effect in group A than that in group B. Conclusion Fudr is a safe, effective and low toxicity drug, it's useful in treating for squamous cell carcinoma of head and neck.