子宫内膜癌术后辅助放疗的临床观察

Effect of postoperative radiotherapy on endometrial carcinoma

目的 评价高危子宫内膜癌术后辅助放疗的价值。方法 具有高危因素的子宫内膜癌 184例 ,12 6例接受术后放疗 ,5 8例行单纯手术 ,比较两组的局部复发率及 5年生存率。结果 在早期 (Ⅰ、Ⅱ期 )子宫内膜癌 ,术后放疗组与单纯手术组的局部复发率分别为 7.5 %、2 1.9% (P <0 .0 1)。 5年生存率分别为 88.1%、6 8.2 % ,两组差异呈显著性 (P <0 .0 1) ,在晚期 (Ⅲ、Ⅳ期 )子宫内膜癌 ,两组的 5年生存率为 35 .6 %、2 9.4 % (P >0 .0 1)。结论 术后辅助盆腔放疗可以提高具有高危因素的Ⅰ、Ⅱ期子宫内膜癌的 5年生存率 ,降低局部复发率 ,对于Ⅲ、Ⅳ期子宫内癌 ,术后放疗不能改善 5年生存率。

Objective To evaluate the effect of postoperative radiotherapy on high\|risk endometrial carcinoma. Methods 126 patients were treated with surgery plus postoperative radiotherapy, 58 patients were treated with surgery alone as control. The rate of recurrence and 5\|year survival rate were observed. Results Between patients receiving surgery alone and surgery plus postoperative radiotherapy, there was statistically significant difference in rate of local recurrence and 5\|year survival rate in Patients with high\|risk stage ⅠorⅡedometrial carcinoma ( P <0.01), but there was no statistical difference in 5\|year survival rate in advanced patients. Conclusion Postoperative radiotherapy can reduce the rate of local recurrence and increase the 5\|year survival rate in Patients with high\|risk surgical stage ⅠorⅡendometrial carcinoma.