24例女阴恶性黑色素瘤临床病理分析

A clinicopathology analysis of malignant melanoma in primary female genital tract

目的 研究女阴恶性黑色素瘤的临床和病理学特征。方法 复习临床、病理学资料 ,全部病例进行随访 ,免疫组织化学方法用S P法。结果 2 4例中发生于外阴 13例 ,阴道 7例 ,宫颈 4例。 17例获得随访 ,1年内死亡 6例 ,2年 4例 ,3～ 4年 3例 ,4例存活 5年以上。免疫组织化学染色nm2 3阳性 14例中淋巴结转移者仅 2例阳性 ,9例者淋巴结转移者中 6例 p5 3蛋白染色阳性。 结论 女阴恶性黑色素瘤恶性程度高。nm 2 3的表达与淋巴结转移呈负相关 ;p5 3表达者淋巴结转移比淋巴结阴性病例高 ,有预后意义。

Objective To investigate the clinic pathologic characteristics of malignant melanoma in primary female genital tract. Methods The clinical data of 24 cases malignant melanoma of female genital tract was analysed retrospectively.S\|P method was used for immunohistochemical staining. Results 24 patients of melanoma in primary female genital tract,13 cases occurred in valvar,7 vagina,4 cervical. 17 patients were followed up,6. cases died in 1 year,4 cases in 2 years and 3 cases in 3～4 years respectively, survival time of 4 cases was over 5 years.nm23 expressed positive in 14 cases. p53 expression was positive in 6 cases among 9 cases with lymph nodes metastasis.Conclusion The prognosis of melanoma in primary female genital tract was poor,and related to clinical stage,the expression of nm23 was negative relation to lymph nodes metastasis,the expression of p53 indicated highly metastatic rate and poor prognosis.