双环醇治疗慢性乙型肝炎60例临床疗效观察

Clinical observation of bicyclol in treating chronic hepatitis B with 60 cases

目的 :评价双环醇治疗慢性乙型肝炎的临床疗效。方法 :选择 117例HBsAg,HBeAg ,HBV DNA均为阳性的慢性乙型肝炎患者 ,随机分成治疗组 6 0例 ,予双环醇 75mg·d-1,po ,tid ,疗程 6mo。对照组 5 7例 ,予苦参素治疗 ,4 0 0mg·d-1,im ,疗程为6mo。结果 :治疗结束时 ,治疗组ALT复常率 6 1 7%,对照组为 33 3%,有非常显著性差异 (P <0 0 1) ,而HBeAg ,HBV DNA的阴转率治疗组为 2 5 %,36 7%;对照组为 2 9 8%,4 0 3%,2组无显著性差异 (P >0 0 5 )。结论 :双环醇是治疗慢性乙型肝炎较理想的保肝抗病毒药物。

AIM: To observe the clinical efficacy of bicyclol (Baisano) in treating chronic hepatitis B. METHODS: One hundred and seventeen patients with HBsAg, HBeAg, HBV DNA all positive were randomly divided into 2 groups. Sixty patients as a treatment group received bicyclol 25 mg, po , tid, for 6 mo. Fifty seven patients as a control group were administered oxymatrine (Boertaili) 400 mg·d -1 , im, for 6 mo. RESULTS: After completion of therapy, the recovery rate of ALT was 61.7% and 33.3% in these 2 group, respectivily. There was significant difference between 2 groups ( P <0 01). The negative rate of HBeAg, HBV DNA was 25% and 36.7% in the treatment group while it was 29.8% and 40.3% in the comparison group. There was no obvious difference ( P >0 05). CONCLUSION: Bicyclol is a useful drug that can improve the liver function and inhibit HBV replication.