安徽省山林地区肾综合征出血热微小疫源地及汉坦病毒新亚型的发现

Discovery of two sub-types of Hantanvirus in Anhui mountain areas

目的 了解安徽省山林地区是否存在肾综合征出血热 (HFRS)微小疫源地 ,同时对所获毒株进行型别鉴定。方法 于 2 0世纪 90年代中期对海拔 14 0 0m的大别山区和 16 0 0m的皖南山区采用流行病学、地理流行病学、血清学、病原学及分子流行病学方法进行了调查。结果 从社鼠肺标本中分离出 2株HFRS病毒 ,经鉴定均为A型。核酸序列分析显示 2株病毒均与标准HTN 76 118株差异较大。结论 证实山林区存在HFRS微小疫源地 ,2株病毒为HTNV新亚型。

Objective To investigate the existence of hemorrhagic fever with renal syndrome (HFRS) foci in high mountains and forest areas. Methods A survey was conducted in the areas of 1 400 meter altitude in Dabie mountain and of 1 600 meter altitude in Wannan mountain in the mid 1990's using methods relcted to epidemiology, geographic epidemiology, serum epidemiology, pathogenic and molecular epidemiology. Results Two strains of HFRS viruses were isolated from pulmonary tissues of Rattus niviventer and both of them were identified as A types. The analysis of the nuclei sequence showed that there were significant differences between both sub types and HTN 76 118. Conclusion It was confirmed that there were HFRS foci in the areas with 2 strains possible new sub types of HFRS.