食管鳞状细胞癌中p53蛋白和PCNA表达的研究

Study on Expression of p53 and PCNA in Esophageal Squamous Cell Carcinoma

目的 :研究p5 3蛋白和PCNA在食管鳞状细胞癌中表达的意义。方法 :应用免疫组化S P法检测 94例食管鳞状细胞癌中p5 3蛋白和PCNA表达情况。结果 :p5 3蛋白阳性率为 6 5 .96 % ,PCNA阳性率为 85 .11% ,p5 3蛋白阳性、PCNA阳性与肿块的大小、肿瘤的浸润深度、淋巴结转移、病人生存期有关 ,与肿瘤的分级无关。结论 :临床检测p5 3蛋白和PCNA对评价食管癌病人预后有意义。

Objective:To study significance of p53 proteins and PCNA in esophageal squamous cell carcinoma. Methods: Using S P immunohistochemical methods, p53 proteins and PCNA expressions in 94 cases of human esophageal carcinoma were studied. Result: The positive rate of p53 proteins was 65.96%, and the positive rate of PCNA was 85.11%. p53 protein expressions and PCNA expressions were related with the tumor size, depth of invasion, lymph node metastasis, and the patient survival duration.It is not related to degrees of the cancer cell differentition. Conclusions: Examining the expressions of p53 and PCNA may be helpful to predicate the prognosis.