儿童支气管肺炎与血清维生素A、D水平的相关性分析

Clinical Study on the Correlation between Bronchopneumonia and Serum Vitamin A, D Levels in Children

目的:探讨儿童支气管肺炎与血清维生素A、D水平的相关性,提供补充维生素A、D防治支气管肺炎的临床依据。方法:采用病例对照研究,选取2017年1～12月于我科住院治疗的146例支气管肺炎患儿作为观察组,另外选取同期于我院儿童保健科查体的儿童146例作为健康对照组。应用电化学发光法检测维生素A、D水平。用t检验及秩和检验进行组间比较。结果:观察组男59例,女87例,平均年龄(8.66±7.94)月,维生素A、D均值分别为:(1.105±0.659)μmol·L^(-1);(38.563±11.314)nmol·L^(-1)。健康对照组男74例,女72例,平均年龄(9.51±5.80)月,维生素A、D均值分别为:(1.471±0.741)μmol·L^(-1);(41.437±12.406)nmol·L^(-1)。观察组患儿维生素A、D平均水平均低于对照组(P<0.05)。观察组维生素A、D缺乏构成比均高于对照组(P<0.05);维生素A正常构成比低于对照组(P<0.05);维生素A不足构成比两组差异无统计学意义(P>0.05)。两组间维生素D不足及正常构成比差异无统计学意义(P>0.05)。结论:维生素A、D不足在肺炎儿童中普遍存在,补充维生素A、D可能有助于支气管肺炎患儿的防治。

Objective:To explore the correlation between serum vitamin A and D levels in children with bronchial pneumonia,and to provide guidance for prevention and treatment. Methods:Case-control study was adopted and 146 cases of hospitalized children with bronchopneumonia from January to December in 2017 were the observation group, 146 healthy children who did checkup in healthcare department were as healthy control group in the same period. The electrochemical luminescence method was used to detect vitamin A, D levels, and t test and rank sum test were employed. Results:In the bronchial pneumonia observation group, 59 cases were male and 87 cases were female, the average age was(8.66±7.94)months, and the mean values of vitamin A, D were(1.105±0.659)μmol·L-1 and(38.563±11.314) nmol·L-1 respectively. There were 74 males and 72 females in the control group, with an average age of(9.51±5.80)months, and the mean values of vitamin A, D were(1.471±0.741)μmol·L-1 and(41.437±12.406)nmol·L-1 respectively. The average level of vitamin A, D in the observation group was lower than that in the control group(P<0.05). The constituent ratio of vitamin A, D deficiency in the observation group was higher than that in the control group(P<0.05) and the vitamin A normal constituent ratio in the observation group was lower than that of the control group(P<0.05). There was no statistical significant of the difference in vitamin A lack constituent ratio and vitamin D lack and normal constituent ratio between the two groups(P>0.05). Conclusion:Vitamin A and D deficiency is common in children with pneumonia. Vitamin A and D supplement may help to prevent and treat bronchial pneumonia in children.