成熟、有活性的树突状细胞与肝细胞癌的形成

Absence of Mature and Activated Dendritic Cells at Cancer Nodules from Patients with HCC Relevance to Hepatocarcinogenesis

成熟、有活性的树突状细胞 (DCs)对于活化的肿瘤特异性淋巴细胞在致癌过程中的再生和存活是至关重要的。肝细胞癌 (HCC)和肝硬化 (LC)患者的外周血中CD83阳性的DCs的浓度几乎是相同的。就肝组织而言 ,与LC相比 [(6 6± 10 9)比 (33 3± 2 4 )个DCs 组织切片 ,P <0 0 5 ) ],HCC中的CD83阳性的DCs却明显减少。更重要的是 ,HCC癌结节中完全缺乏CD83阳性的DCs。

Mature and activated dendritic cells (CD83 positive DCs) are essential for the recruitment and survival of activated tumor specific lymphocytes during carcinogenesis.The frequencies of CD83 positive DCs were almost same in peripheral blood from patients with hepatocellular carcinoma (HCC) and cirrhosis of live (LC). However,the numbers of CD83 positive DCs in liver tissues were significant lower in HCC,compared with LC[(6 6±10 9)vs(33 3±24)[BFQB]DCs/ specimen,P<0 05)]. Most importantly,there were no CD83 positive DCs at cancer nodules in HCC. A role of infiltration of activated DCs in liver during hepatocarcinogenesis is shown. . Most importantly,there were no CD83 positive DCs at cancer nodules in HCC. A role of infiltration of activated DCs in liver during hepatocarcinogenesis is shown.