二硫化碳对大鼠脑诱发电位的影响

Effects of Inhaled Carbon Disulfide on Sensory-Evoked Potentials in Rats

以递增浓度的二硫化碳（CS2）对大鼠动式吸入染毒6周。观察了大鼠的模式翻转视觉诱发电位（PREP）、闪光刺激视觉诱发电位（FEP）、皮层体感诱发电位（sEP）和坐骨-胫神经的运动神经传导速度（MCV）。发现视觉神经诱发电位是CS2神经毒性研究的非损伤性敏感指标。另外,结合神经功能的变化,同时测定其组织中铜、锌的含量,为研究CS2神经毒性的机制提供了线索。

An inhalation study with increasing concentrations of CS2 was carried out in rats. The concentrations of CS2 inhaled by rats were 300ppm,600ppm, and 800ppm for every 2 weeks respectively. The effects of CS2 on nervous system were determined by cerebral evoked potentials, peripheral nerve conduction and the contents of copper and zinc in the nervous system. The effects of CS2 on PREP and FEP were observed in the second week after exposure. The changes of SEP and sciatic MNCV appeared in the fourth week. The contents of Cu and Zn in the brain increased in the last week, These results revealed that visual evoked potentials are the sensitive non-invasive index for the study of carbon disulfide neurotoxicity, while the roles of Cu and Zn in the mechanism of this neurotoxicity have not. been verified.