灵芝三萜类化合物对AD衰老模型大鼠学习记忆能力和脑能量代谢的影响

Protective Effects and Mechanism of Ganoderma Lucidum Triterpenoids on Learning and Memory Function of Alzheimer Disease Model Animals

探讨了灵芝三萜类化合物(Ganoderma Lucidum Triterpenoids,GLT)对阿尔茨海默病(Alzheimer disease,AD)的防治作用及作用机制,为临床新药的开发和应用提供参考依据。结果表明AD自然衰老模型大鼠Morris水迷宫检测显示学习记忆障碍,脑组织Na+-K+-AT-Pase活力降低,GLT灌胃2月后,学习记忆成绩明显提高,Na+-K+-ATPase活力增加。提示GLT能提高AD自然衰老模型大鼠的学习记忆能力,其作用可能与改善脑内能量代谢有关。

In order to elucidate the protective effects and mechanism of Ganoderma Lucidum Triterpenoids(GLT) on Alzheimer Disease model animals,two different groups rats was divided.it was found that the model animals exhibited the worse ability in learning and memory and a lower Na+-K+-ATPase activity.The addition of GLT significantly improved the above indexes(P<0.05).GLT can protect AD model animals,GLT improved the learning and memory dysfunction in aging model rats,the following mechanism may be improving energy metabolism in brain.