摘要
目的 :观察血清CA12 5、NSE测定对肺癌的诊断价值。方法 :采用放射免疫分析法对 5 1例肺癌患者和 32例肺良性疾病患者和 6 8例健康人进行血清CA12 5、NSE水平测定。结果 :发现肺癌患者血清CA12 5、NSE水平明显高于肺良性疾病组和正常对照组 (P <0 .0 0 1) ;其增高的程度与肺癌TNM分期具有一定的相关性。血清CA12 5及NSE测定诊断肺癌的敏感性为 6 2 .72 %及 4 9.0 2 % ;特异性为 99%及 98%。结论 :联合检测血清CA12 5及NSE对肺癌的诊断、分期及疗效判断具有重要的临床价值。
Objectiv: To observe value of serum CA125 and NSE assays in the diagnosis of lung cancer. Methods: Contents of serum CA125? NSE were detected by immunoradiometric assay in lung cancer group (51 cases),benign pulmonary diseases(32 cases )and normal control group(68cases). Results: The serum CA125 ? NSE in lung cancer group were significantly higher than those in benign pulmonary diseases group and normal control group ( P <0.001). The degree of increase was directly associated with the lung cancer TNM stage. The sensitivity of serum CA125 and NSE assay in the diagnoses of lung cancer were 62.75% and 49.02% ;the specificity was 99% and 98%. Conclusion:Detection of serum CA125 and NSE is of clinical value for the diagnosis, staging and prognosis in lung cancer.
基金
河南省郑州市自然科学基金项目 (2 0 0 0 15 )
