嗜酸细胞性筋膜炎六例报告

Eosinophilic fasciitis: a clinicopathological analysis of six cases

目的 探讨嗜酸细胞性筋膜炎的临床特征与组织学类型的关系。方法 总结 6例嗜酸细胞性筋膜炎患者的临床资料 ,对肌活检组织进行临床病理研究。结果 6例患者的发病年龄在 15～ 41岁。均表现有较典型的嗜酸细胞性筋膜炎的临床特征。肌活检可见到 3种组织学形态。 (1)肌筋膜炎伴有肌病。 (2 )典型的嗜酸细胞性筋膜炎。 (3)局限性肌筋膜炎。结论 嗜酸细胞性筋膜炎病理观察可有不同的组织学亚型及临床表现。

Objective To mainly discuss the relationship between histologic type and clinic manifestations of eosinophilic fasciitis. Methods Muscle biopsies in 6 cases of eosinophilic fasciitis were evaluated by the clinical, histopathology and enzyme histochemistry. Results All 6 cases were adults aged from 24-41 years (mean 35 years). Clinically, typical eosinophilic fasciitis charactristics were found in all cases. Histologically, three features appeared with diagnostic values. One was eosinophilic fasciitis with myopathy, one, eosinophilic fasciitis and another was focal fasciitis.Conclusions There may appear different histopathologic changes in eosinophilic fasciitis according to its clinic manifestations.