老年高血压患者的血管内皮功能变化及颈动脉内膜中层厚度改变的意义

The significance on changes of endothelial function and intima-media thickness of carotid arteries in senile patients with hypertension

目的 研究老年高血压患者血管内皮功能及颈动脉内膜中层厚度改变情况及其意义。 方法 测定 43例高血压患者血液中血管内皮功能受损特异性标志物NO、ET并采用高分辨率超声技术检测休息时、反应性充血后的肱动脉内径变化及颈动脉内膜中层厚度及斑块。同时与 2 0例正常者进行对比。 结果 老年高血压组肱动脉血流介导性舒张功能明显减弱 ,NO明显低于对照组 ,ET水平明显高于对照组。老年高血压Ⅱ期及Ⅲ期颈动脉内膜中层厚度及斑块发生率较对照组明显增加 (P <0 0 5 ) ,且随斑块严重程度的增加 ,内膜中层厚度呈增厚趋势。

Objective To investigate the change of endothelial function and intima-media thickness of carotid arteries in senile patients with hypertension. Methods The change of plasma endothelin(ET) and nitric oxide(NO) levels was examined,and with we measured endothelium-dependent relaxing function and IMT of carotid arteries by using high-resolution ultrasound in 43 patients with essential hypertension and there ware 20 normal subjects as the control. Results In senile hypertensive patients group,IMT of carotid arteries was higher and flow-mediated diatation was much reduced compared with control group.Serum No level was much lower and ET level was much higher than control group. The IMT of carotid arteries was higher in hypertensive patients than those in normal subjects(P<0.05).There was an increasing trend for IMT with the severity of plaque. Conclusion Increases in IMT of carotid arteries and impairment of endothelium-dependent vasolidation are related to atherosclerosis in early stage of senile hypertensive patients.