急性胰腺炎患者并发多器官功能障碍综合征的机制探讨

The mechanism study of acute pancreatitis complicated with MODS

目的 探讨急性胰腺炎患者并发多器官功能不全综合征 (MODS)的机制 ,为临床防治MODS提供新的思路。方法 收集急性胰腺炎 (AP)患者 63例 ,按APACHE -Ⅲ评分分 3组 ,并测定外周血内毒素水平及外周血单个核细胞 (PBMC)中核因子 -κB (NF -κB)的活性 ,观察与MODS发生的关系。结果 ①AP患者出现了内毒素血症 ,其发生率为 75 64 %。而且与病情严重度有关 ;②AP患者PBMC的NF -κB活性显著增高 ,且与疾病严重程度明显相关。结论 持续内毒素血症、NF

Objectives To probe into the mechanism of the acute pancreatitis complicated with MODS, to provide a new thinking for the prevention and treatment of MODS Methods Sixty three pancreatitis patients were divided into three groups according to their APACHE-Ⅲ score, plasma endotoxin level, nuclear factor-κB (NF-κB) activity in PBMC were determined Results The incidence of endotoxemia was 75 64%, and the NF-κB activity in PBMC was enhanced, which was related to the severity Conclusions Continuous endotoxemia and NF-κB activation may be one of the mechanisms of the occurrence and development of MODS in patients with acute pancreatitis