p53和PCNA联合表达与林州市食管癌患者预后的关系

Combining expression of p53 and PCNA and its relationship with esophageal cancer prognosis on the patients from the high-incidence area for esophageal cancer in Linzhou, Henan

目的 从分子水平上探索食管癌相关基因的变化 ,寻找敏感、特异的预后指标。方法 对 114例食管癌高发区林州市的食管癌患者进行五年随访 ,采用组织病理学和免疫组织化学等方法检测p5 3和增殖细胞核抗原 (PC NA)在食管癌组织中的表达状况 ,用Kaplan -Meire法分析p5 3和PCNA联合表达与林州市食管癌患者预后的关系。结果 p5 3和PCNA同时高表达的食管癌患者生存期小于同时低表达者 ,p5 3和PCNA联合表达对于判断食管癌预后的意义优于单独以PCNA作为预后指标。结论 单一指标判断预后具有一定的局限性 ,多因素、多指标综合评价食管癌患者的预后可能更好地反映患者的实际情况 。

Objectives To further characterize the possible relationship between the molecular changes and esophageal carcinoma prognosis and to elucidate the possible mechanisms of esophageal carcinoma carcinogenesis Methods 114 patients were followed up more than five years, immunostaining (ABC) method was employed to detect the alternation of p53 and PCNA in EC, Kaplan-Meier were used for survival analysis Results Patients in coincidence low-expression group obviously survived longer than those in coincidence high-expression group, and the difference was significant ( P <0 05) Conclusions Esophageal cancer patients with p53 and PCNA coincidence low-expression survived longer than those with coincidence high-expression, indicating that multiple parameters may be better than single parameter in evaluating the prognosis