雾化吸入L-精氨酸治疗高原肺水肿对血液流变性的影响

Effect of L-Arginine on hemorheology in Patients with High Altitude Pulmonary Edema

目的 探讨左旋精氨酸 (L -Arg)对高原肺水肿 (HAPE)患者血液流变性的影响。 方法 在海拔 370 0米采用氧气驱动雾化吸入L -Arg治疗高原肺水肿患者 9例为L -Arg组 ,并与吸入低浓度NO混合气治疗 8例高原肺水肿患者为NO组作对照。分别测定HCT、ηb、ηp、ηr、IR、TK、VAI和TEL等血液流变学指标。 结果 NO组和L -Arg组治疗前较治愈后的 ηb、ηp、ηr、VAI、TEL均增高非常显著 (P <0 .0 1) ,HCT、TK、IR无统计学差异 (P >0 .0 5 )。NO组和L -Arg组比较 ,各指标均无统计学差异 (P >0 .0 5 )。 结论 L -Arg治疗对HAPE有效 ,通过调节提高NO水平而改善血液循环 ,比较经济简便 ,易于推广应用。

Objective To study the effect of the L-Arginine(L-Arg) on hemorheology in patients with high altitude pulmonary edema(HAPE).Methods 8 patients with HAPE were treated by inhaling L-Arg at 3700m altitud,compared with 8 subjects treated by inhaling low density nitric oxide(NO),and their plasma content of HCT?ηb?ηp?ηr?IR?TK?VAI and TEL were determined after treatment.Results After treatment,two groups content of ηb?ηp?ηr?VAI?TEL is decreased notably( P <0.01),HCT TK IR were not statistically significant. (P >0.05).Compared NO group with the L-Arg group,there is no statistics discrepancy ( P> 0.05).Conclusion Inhaling L-Arg could improve activity of blood circulation and the level of NO in HAPE,and it is easy to operate and worth applying and disseminating.