羟基喜树碱联合化疗治疗晚期胃肠道癌疗效观察

Efficacy of Hydroxycamptothecin Based Combination Chemotherapy in Advanced Gastrointestinal Ttract Cancer

目的:观察羟基喜树碱(HCPT)联合化疗方案对晚期胃肠道癌的疗效和不良反应。方法:89例晚期胃肠道癌随机分为两组。治疗组应用HCPT联合5-氟脲嘧啶(5-FU)、甲酰四氢叶酸钙(CF),对照组应用丝裂霉素(MMC)联合5-FU、CF,并作对比观察。结果:治疗组总有效率为46.51%,对照组总有效率为26.09%,两组有显著性差异(P<0.05)。两组不良反应无显著性差异(P>0.05)。主要为消化道反应及白细胞减少,但大多为Ⅰ、Ⅱ度,不影响治疗。结论:HCPT联合化疗方案治疗晚期胃肠道癌安全有效,是一种可行的方案。

Objecti ve :To observe the efficacy and toxicity of hydroxycamptothecin(HCPT)based combi nation chemotherapy in advanced gastrointestinal tract cancer.Methods:89pati ents with advanced gastrointestinal tract cancer were randomly devided into two groups.The treatment group was treated using HCPT with5-fluorouracil(5-F U)/Leucovorin(CF).The control group was treated using Mitomycin-C(MMC)wi th5-FU/CF.These two groups were comparatively studied.Results:The overall response rate of the treatment group was46.51%,while the control group was26.09%with significant difference(P<0.05).The major toxicities included anorexia?nausea?vomiting and leukopenia,but it was tolerable in mo st of the patients.Conclusion:HCPT based combination chemotherapy is effective and safe for advanced gastrointestinal tract cancer.