CEA、CYFRA21-1、NSE联合检测在周围型肺癌中的诊断价值

Diagnostic Utility of Tumor Markers in Peripheral Type Lung Carcinoma

目的:探讨联合检测血清和支气管肺泡灌洗液CEA、CYFRA21-1、NSE标记物在周围型肺癌中的诊断价值。方法:对81例周围型肺癌患者进行血清及支气管肺泡灌洗液CEA、CYFRA21-1、NSE检测并与30例良性病变进行对照。CEA、CYFRA21-1采用放射免疫法测定,NSE用酶联免疫法测定。结果:肺癌患者血清及支气管肺泡灌洗液CAE、CYFRA21-1、NSE检测值均高于良性病变组。支气管肺泡灌洗液CEA界值35.50ng/ml,诊断灵敏度80.02%,特异度63.33%,总体诊断符合率70.30%。联合检测血清CEA和支气管肺泡灌洗液CEA经Logistic多元回归方程计算、得出公式:血CEA×1.2+BALFCEA>50ng/ml,诊断符合率84.68%,灵敏度87.65%,特异度71.70%。结论:联合检测血清和支气管肺泡灌洗液CEA、CYFRA21-1、NSE对诊断周围型肺癌有一定的帮助。

Objective:The aim of this study i s to evalute the diagnostic utility of CEA?YFRA21-1,NSE determinations in th e blood and bronchoalveolar lavage fluid of patients with peripheral type carcin oma of lung.Methods:Eighty-one cases of peripheral type carcinoma of lung a nd30cases of benign lung disease as control were studied..Levels of CEA?YFR A21-1in blood and bronchoalveolar lavage fluid were measured by radio immuno assay,and the level of NSE was measured by enzyme immunoassay.Results:There was significant difference of CEA,CYFRA21-1NSE levels between the lung can cer and benign disease groups(P<0.05).The sen-sitivity,specificity and accuracy rate of CEA in bronchoalveolar lavage fluid were80.02%,63.3 3%and70.30%respectively,while the CEA velue in bronchoalveolar lavage f luid was35.5%.By logistic regression and with a formula of blood CEA×1 .2+BALF CEA>50ng /ml,the sensitivity,specificity rates were87.65% and71.7%respectively.Conclusion:These findings suggest that a combination of CEA?CYFRA21-1?NSE assay in blood and bronchoalveolar lavage fluid can be a useful addition in the diagnosis of peripheral type carcinoma of lung.