自固化磷酸钙人工骨复合骨形成蛋白在牙槽骨缺损修复中的应用

Application of Autosolidification Calcium Phosphate Cement with Bone Morphogenetic Protein in Repairing Alveolar Bone Defects

目的 探讨自固化磷酸钙人工骨(autosolidification calcium phosphate cement,ACPC)复合骨形成蛋白(bone morphogenetic protein,BMP)对牙槽骨缺损修复的生物学作用。方法将ACPC/BMP即刻植入拔牙术后患者牙槽创口,随访24周,通过临床检查和CCD数字化摄片观察牙槽骨缺损修复情况。结果实验位点无炎症、过敏和毒性反应发生,实验组患者牙槽嵴骨量吸收较空白对照组少,外形维持较好。结论BMP/ACPC复合骨兼具骨的引导性和诱导性,可促进新骨沉积钙化,即刻植入拔牙创利于增加牙槽骨量,维持牙槽外形,但材料降解性存在不足。

Objective To study the effects of artificial bone composition of autosolidification calcium phosphate cement with bone morphogenetic protein on rehabilitation alveolar socket bone defects in clinic. Methods In Clinic,we immediately implant ACPC/BMP into the extraction socket,and the results were evaluated with general observation and X-ray for 24 weeks. Result No apparent inflammation was observed during the observation periods, and the height and width of alveolar were maintained better than the control. Conclusion The results suggest that ACPC/BMP had osteoconductivity and could promote osteoinduction. It could be used as a material for enhancing alveolar bone defects repairing.