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银离子表面注入改性硅橡胶抗菌性能及生物相容性的初步研究 被引量:2

Antibacterial property and biocompatibility of silver ion implanted silicone rubber
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摘要 目的采用银离子对普通硅橡胶进行表面注入改性,以期制备一种抗菌性能及生物相容性良好的整形填充材料。方法用高能离子注入机向普通硅橡胶表面注入银离子,对改性后的硅橡胶采用扫描电子显微镜(scanning electron microscope,SEM)、X射线光电子能谱仪(X-ray photoelectron spectroscopy,XPS)、傅里叶红外光谱仪(Fourier transform infrared spectrometer,FTIR)以及水接触角检测仪对表面形貌、元素组成、化学结构以及亲/疏水性进行检测。选用大肠杆菌进行抑菌圈、抗细菌黏附性实验,初步探究其抗菌性能。采用体外及体内实验对生物相容性进行评价。结果 SEM观察各材料的表面形貌无明显差异;XPS结果显示银离子已注入材料表面;FTIR观察各材料图谱无明显变化;水接触角检测结果显示,银离子注入硅橡胶水接触角随注入剂量加大而逐渐变小,逐渐呈现出亲水性趋势。抑菌圈结果显示银离子注入硅橡胶可以使抑菌圈直径>7 mm,呈现出抑菌效果;抗细菌黏附性实验显示,改性硅橡胶具有明显的抗菌性。生物相容性评价显示,与普通硅橡胶比,银离子注入硅橡胶均有较好的特性。结论采用银离子注入技术对硅橡胶进行表面改性可以明显提高硅橡胶的亲水性能和抗菌能力以及生物相容性。 Objective To change the surface of silicone rubber by silver ion implantation technology in order to obtain an implantable silicone rubber with antibacterial property and good biocompatibility.Methods High-energy ion implantation machine was used for the silver ion implantation on the surface of silicone rubber. After then,the surface properties of 3 doses of silver ion implanted silicone rubber( 3 × 1015,1 × 1016 and 3 × 1016 ion/cm2) were analyzed by scanning electron microscopy( SEM),X-ray photoelectron spectroscopy( XPS),Fourier transform infrared spectrometry( FTIR) and water contact angle test for surface morphology, elemental composition, chemical structure and hydrophilic/hydrophobic properties. The antibacterial properties of these materials were conducted by bacterial inhibition ring test and antibacterial adhesion assay using E. coli. The biocompatibility was evaluated by in vitro and in vivo experiments. Results SEM indicated that there was no obvious difference in the surface morphology of silicone rubber with different doses or without silver ion implantation. XPS showed that the silver ions were injected in the surface of silicone rubber but the content of silver ions had no change with the different doses of silver implantation.FTIR indicated that there was no obvious change in organic functional groups on the surface of 4 kinds of silicone rubber. Ion implantation significant reduced water contact angle with the increase of silver doses,indicating a trend of hydrophobic property of silicone rubber. The bacterial inhibition ring test showed that the diameter of inhibition ring is over 7 mm in the silver ion implanted silicone rubber,showing antibacterial activity. The antibacterial adhesion assay indicated that the silver ion implanted silicone rubber have decreased bacterial adhesion. The in vitro and in vivo experiments suggested the silver ion implanted silicone rubber had good biocompatibility. Conclusion The silver ion implantation can achieve a new material with good surface properties and increased antibacterial property.
出处 《第三军医大学学报》 CAS CSCD 北大核心 2015年第19期1914-1920,共7页 Journal of Third Military Medical University
基金 重庆市创新青年科技人才培养项目(cstc2013kjrc-qnrc0075)~~
关键词 硅橡胶 离子注入 银离子 表面注入改性 抗菌性 生物相容性 silicone rubber ion implantation silver ion surface modification antibacterial property biocompatibility
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