摘要
目的比较腹腔镜肝切除术(laparoscopic hepatectomy,LH)与射频消融术(radiofrequency ablation,RFA)治疗复发性肝癌的围术期及术后生存结果,为复发性肝癌患者治疗方式选择提供高级别循证医学证据。方法 2016年9月至2017年9月共入组80例复发性肝癌患者,通过随机数字表法随机分至LH组和RFA组。应用前瞻性随机对照研究,分析两组患者围术期指标及总体生存期和无瘤生存期,通过COX比例风险模型分析影响患者术后再次复发的危险因素。结果中期随访结果显示,LH组与RFA组患者的平均生存期差异无统计学意义[(19.3±6.8)月vs(18.6±6.2)月,P=0.293]。LH组患者1、2年总体生存率为:92.3%和89.7%,RFA组为:85.4%、80.5%。LH无瘤生存期与RFA比较差异有统计学意义[(16.4±8.5)月vs(8.3±7.2)月,P=0.000]。两组1、2年无瘤生存率分别为LH:69.2%、51.3%,RFA:26.8%、22.0%。COX比例风险模型分析显示手术方式及患者术前甲胎蛋白(alpha fetoprotein,AFP)水平是影响患者再次复发的危险因素。结论中期随访结果显示,对选择性复发肝癌患者,腹腔镜肝切除术后2年无瘤生存率高于射频消融术。
Objective To compare the perioperative and postoperative survival outcomes of laparoscopic hepatectomy(LH) and radiofrequency ablation(RFA) in the treatment of recurrent hepatocellular carcinoma(RHCC) in order to provide high-level evidence-based medical evidence for the treatment. Methods From September 2016 to September 2017, a total of 80 RHCC patients were prospectively enrolled and randomly assigned to the LH and RFA groups. A prospective randomized controlled study was used to analyze perioperative factors, overall survival and disease-free survival of patients between the 2 groups, and COX proportional risk model was used to analyze the risk factors for postoperative recurrence. Results According to this interim follow-up analysis, there was no significant difference in the overall survival time between the LH group and the RFA group(19.3±6.8 vs 18.6±6.2 months, P=0.293). The 1-and 2-year overall survival rates were 92.3% and 89.7% in the LH group and 85.4% and 80.5% in the RFA group. There was statistical significant difference in disease-free survival time between the LH group and the RFA group(16.4±8.5 vs 8.3±7.2 months, P=0.000). The 1-year and 2-year disease-free survival rates were 69.2% and 51.3% in LH group, and 26.8% and 22.0% in RFA group. COX proportional risk model analysis showed that the surgical procedures and preoperative alpha fetoprotein(AFP) level were the risk factors for re-recurrence. Conclusion Our interim follow-up analysis shows that, in selective RHCC patients, LH has a better 2-year disease-free survival rate than RFA.
作者
刘嘉龙
黄登
曹利
王小军
李建伟
陈建
马宽生
郑树国
LIU Jialong;HUANG Deng;CAO Li;WANG Xiaojun;LI Jianwei;CHEN Jian;MA Kuansheng;ZHENG Shuguo(Institute of Hepatobiliary Surgery,First Affiliated Hospital,Army Medical University(Third Military Medical University),Chongqing,400038,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2019年第5期467-472,共6页
Journal of Third Military Medical University
基金
第三军医大学西南医院重大领域技术创新项目(SWH2016ZDCX2015)~~
关键词
腹腔镜
肝切除术
肝细胞癌
射频消融
复发
生存率
laparoscopy
hepatectomy
hepatocellular carcinoma
radiofrequency ablation
recurrence
survival rate