基于ClinicalTrials.gov数据的美国陆军医学研究与物资部临床试验特点分析

Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data

目的分析美国陆军医学研究与物资部(U.S. Army Medical Research and Materiel Command,USAMRMC)临床试验特点,了解美国军队军事医学研究的主要动向。方法通过ClinicalTrials.gov数据库检索USAMRMC发起或参与完成的临床试验,从主题词、研究内容、进展状态、临床分期、任务分配及地域分布等方面对临床试验项目进行统计和分析。结果 USAMRMC主要关注于感染性疾病、创伤及神经系统疾病的临床试验,并在上述疾病的疫苗、药物和医疗器械研发中投入大量研究力量。其主导或参与的临床试验中约57.7%已完成并公布研究结果,77.9%在美国本土组织开展,43.1%由美国军队医学机构直接参与。结论 USAMRMC主要依托美国本土力量,通过高效的军地协作机制,在战场传染病防治、战伤救治等的基础和临床研究方面开展了大量工作;启示我国军事医学研究要高度重视地域性疾病防治,强化关键核心技术的协同创新。

Objective To analyze the clinical trials carried out by the U.S.Army Medical Research and Materiel Command(USAMRMC)to understand the general trends of US military medical researches.Methods We retrieved the data of the clinical researches sponsored or participated by the USAMRMC from ClinicalTrials.gov and analyzed the data in terms of the subject words,research contents,progress,clinical stages,task allocation and geographical distribution of the clinical registers.Results The USAMRMC focuses on researches of infectious diseases,trauma and nervous system diseases,and invested heavily on the development of vaccines,drugs and medical equipment.About 57.7%of the clinical researches sponsored or participated by the USAMRMC have been completed and the results have been published;77.9%of the studies were carried out by the local institutions in the USA,and the military medical institutions participated directly in 43.1%of the studies.Conclusion Relying on the local institutions and efficient military-civilian cooperations,the USAMRMC has carried out considerable work in pre-clinical and clinical studies.The practice of the USAMRMC suggests the importance of studies for prevention and treatment of regional diseases and of the collaborative innovation of key technologies between the civilian and military institutions.