不明原因疾病——“阴性艾滋病”的研究进展

Progress of a cause-unidentified disease: negative AIDS

近年来,我们研究小组跟踪观察了一群不被临床医生识别的、被称为'阴性艾滋病'或恐艾症的'患者'。由于'患者'主诉症状与临床常规检测结果不一致,往往被作为心理问题予以处置。调查显示,大多数'患者'是在不安全性行为后不久即发生类似感冒、呼吸道感染、肠道感染的症状,急性期后又出现持续、迁延的慢性症状,涉及咽喉、皮肤、肌肉、骨骼、神经等系统。'患者'因疾病所致的衰弱,生活质量明显下降。初步的血清学指标测试显示,'患者'体内存在明显的免疫功能异常及炎性反应。此外,其肠道细菌种类也发生了明显变化。进一步研究表明,'阴性艾滋病''患者'与国际学术界报道的慢性疲劳综合征(chronic fatigue syndrome, CFS)在症状特征和认识历程方面非常相似。2015年,美国卫生部门确认CFS属于具有生物学基础的疾病,不是纯粹的心理问题。最新的研究信息显示,CFS与病原体感染有明显的关联,'患者'体内呈现免疫功能障碍,激素调节、新陈代谢和氧化应激反应异常等现象。由此,我们认为'阴性艾滋病''患者'可能是CFS的一个病例亚组,其症状是因病原体感染引起的系列病理反应所致。现有临床常规检测指标项目的局限可能人为掩盖了疾病的危害效应。

In recent years,our research team has followed up and observed a group of'patients'who are unknown by clinicians and called as'negative AIDS'or'AIDS phobia'.Because the complaint symptoms of these'patients'are not consistent with the results of clinical routine tests,they are often treated as patients with psychological disorders.Our questionnaire investigation showed that most of the'patients'have symptoms similar to cold,respiratory tract infection and intestinal infection shortly after an unsafe sexual behavior.And after acute period,the chronic symptoms persist and delay,involving the pharynx,larynx,skin,muscle,skeleton,nerve and other systems.These'patients'are weakened by illness,and loss of the quality of life.The preliminary tests about serological indicators showed that there are obvious immunological abnormalities and inflammatory reactions in vivo.In addition,the analysis of gut microbiota diversity also showed significant changes.Further literature studies showed that'negative AIDS'patients are very similar to chronic fatigue syndrome(CFS)reported by international academic community in terms of symptomatic characteristics and cognitive process.In 2015,the U.S health departments confirmed that CFS is a biologically based disease,not a purely psychological problem.Recent research information shows that CFS is significantly associated with pathogenic infections.The patients present immune dysfunction and abnormal response in hormone regulation,metabolism and oxidative stress reaction.In summary,we could propose that the'negative AIDS'patients may be a subgroup of CFS,whose symptoms are induced by a series of pathological reactions caused by pathogen infection.The limitations of current routine clinical indicators could artificially cover the hazard the disease.