外阴阴道假丝酵母菌病严重程度影响因素的Logistic回归分析

Logistic regression analysis of the factors related with severity of vulvovaginal candidiasis

目的:分析外阴阴道假丝酵母菌病(VVC)疾病严重程度的相关影响因素。方法:将2011年8月~2015年8月就诊于天津医科大学总医院普通妇科门诊的237例重度VVC患者及同期490例轻中度VVC患者作为研究对象进行病例对照研究。采用Logistic回归模型进行单因素及多因素分析。结果:(1)单因素分析显示,年龄≥30岁(OR=0.658,95%CI为0.481~0.899,P=0.009)、已婚(OR=0.560,95%CI为0.394~0.794,P=0.001)、采用自然避孕法避孕(OR=0.588,95%CI为0.359~0.965,P=0.036)、有妊娠史(OR=0.565,95%CI为0.411~0.777,P=0.000)、有阴道分娩史(OR=0.557,95%CI为0.371~0.835,P=0.005)是重度VVC的保护因素。白假丝酵母菌感染(OR=5.678,95%CI为2.180~14.789,P=0.000)是重度VVC的危险因素。对食物、药物或花草过敏(OR=1.713,95%CI为0.982~2.988,P=0.058)是重度VVC的可疑危险因素。(2)多因素分析显示,白假丝酵母菌感染(OR=4.593,95%CI为1.700~12.414,P=0.003)以及对药物、食物或花草过敏(OR=2.172,95%CI为1.059~4.458,P=0.034)是重度VVC的独立危险因素。结论:白假丝酵母菌感染以及对药物、食物或花草过敏是重度VVC的独立危险因素。

Objective:To identify the risk factors associated with severity of vulvovaginal candidiasis(VVC).Methods:A prospective case-control study was implemented from Aug.2011 to Aug.2015.A total of 237 women with severe VVC were enrolled as study participants.Controls were 490 women with moderate VVC.Univariate and multivariate logistic regression analysis were used for statistical evaluation.Results:According to univariate analysis,age of more than 29 years old(OR = 0.658,95% CI:0.481 ~ 0.899,P = 0.009),married status(OR =0.560,95% CI:0.394 ~ 0.794,P = 0.001),use of natural family planning method for contraception(OR = 0.588,95% CI:0.359 ~ 0.965,P = 0.036),history of pregnancy(OR = 0.565,95% CI:0.411 ~ 0.777,P = 0.000),and history of natural labor(OR = 0.557,95% CI:0.371~ 0.835,P = 0.005)were protective factors for severe VVC.On the contrary,infected by Candida albicans(OR = 5.678,95% CI:2.180 ~ 14.789,P = 0.000)was a risk factor for severe VVC.Allergy to drugs,foods or flowers(OR = 1.713,95% CI:0.982 ~ 2.988,P = 0.058)was a potential risk factor for severe VVC.In the multivariate analysis,infected by Candida albicans(OR =4.593,95% CI:1.700 ~ 12.414,P =0.003)and allergy to drugs,foods or flowers(OR =2.172,95% CI:1.059 ~ 4.458,P = 0.034)were independent risk factors for severe VVC.Conclusions:Infection of Candida albicans and allergy to drugs,foods or flowers are independent risk factors for severe VVC.