定量脑电图与抗精神病药物疗效的关系

The relation of QEEG with the therapeutic effect of antipsychotic drugs

目的观察氯丙嗪、氟哌啶醇定量脑电图与临床疗效之间的关系。方法采用病人自身对照方法，将６４例精神分裂症病人服药２周时，根据定量脑电图θ频段功率值是否增高，分为增高组（Ａ组）和无改变两组（Ｂ组），并比较两组第１２周临床疗效。结果 氯丙嗪、氟哌啶醇服药后，定量脑电图表现为额、中央、顶、枕θ频段功率值增高，经统计学处理有显著性差异（Ｐ＜０．０５）。两组疗效比较，经统计学处理有非常显著性差异（Ｐ＜０．０１）。结论氯丙嗪、氟哌啶醇定量脑电图可以作为对精神分裂症临床疗效判定和预测的一项客观指标。

Objective To observe the relationship of QEEG with the therapeutic effect of chlorpromazine and haloperidol. Method Sixty - four patients were divided into groups(group A with increased θ waves and group B without θ waves alteration) according to the θ waves finding in two weeks after taking chlorpromazine and halperidol, and the clinical therapeutic effects of the two groups were compared. Result group A showed a significant increase of θwaves. however, θ waves showed no change in the group B. A significant difference of therapeutic effect was noted between the two groups. Conclusion Whether chlorpromazine and haloperidol induce an increase of θ waves or not might be an index for judgement of the therapeutic effect of chlorpromazine and haloperidol on schizophrenia.