支气管哮喘患者腰椎和股骨近端骨密度测量

Measurement of bone mineral density of the lumbar spine and the proximal femur in asthmatic patients

目的 观察接受糖皮质激素（ＧＣ）治疗的支气管哮喘患者骨矿物质密度的变化。方法采用双能Ｘ线骨密度仪（ＤＥＸＡ）测量２６例接受ＧＣ治疗的支气管哮喘患者和年龄、性别匹配的２６例正常健康者的腰椎２～４(Ｌ２～４)和右侧近端股骨（股骨颈、大转子和Ｗａｒｄ’ｓ三角区）的骨密度（ＢＭＤ）。结果接受 ＧＣ治疗支气管哮喘患者 Ｌ２～４、右侧股骨近端的 ＢＭＤ测量值（ｇ／Ｃｍ２） 明显低于年龄和性别匹配的正常健康者，且与ＧＣ用药时间呈显著负相关。结论接受ＧＣ治疗支气管哮喘患者存在明显的骨质丢失，并与ＧＣ用药时间密切相关。

Objective To observe the changes of bone mineral density （BMD）in glucocorticoids treated asthmatic patients. Method BMD of the lumbar spine(L2～4and the proximal femur（femoral neck, ward’s triangle, and trochanter major） was measured using dual energy X-ray absorptiometry（DEXA） in 26 asthmatic patients and 26 normal subjects matched for age, sex, and menopausal status. Result There was a significant decrease（P< 0. 001 ） in BAD（g/cm2） in patients group at the L2～4 and the proximal femur（femoral neck, ward’s triangle, and trochanter major）as compared to normal subjects（P < 0.001 ）. There was a significant negative correlation between agematched z-score of BMD at the L2～4 and the proximal femur and duration of therapy（r = - 0. 40 ～ - 0. 50, P < 0. 05, n = 26）. Conclusion These results suggest that the reduction of BMD was related to the. duration of therapy in glucocorticoids-treated asthmatics.