肺癌立体定向放疗临床研究

The clinical study of the lung cancel treated by sterotacticradiotherapy

目的 探讨立体定向放疗（ＳＲＴ）治疗肺癌的方法和临床疗效。方法 采用ＳＲＴ治疗与常规放疗（ＣＦＲ）比较。结果 ＳＲＴ组局部消退率８８．５％（４６／５２），局部控制率９２．３％（４８／５２），１年生存率６３．５％（３３／５２）。ＣＲＦ组：局部消退率６４．９％（３７／５７），局部控制率７５．４％（４３／５７），１年生存率４２．１％（２４／５７），两组对照差异有显著意义（Ｐ＜０．０５）。结论 ＳＲＴ治疗肺癌可缩短全程放疗时间，近期疗效明显，远期疗效有待扩大病例观察。

Objective To study the method and effect of the lung cancer treated by stereotactic radiotherapy(SRT). Method 52 patients treated by SRT are compared with 57 patients treted by conventional fraction radiotherapy(CRR). Result SRT group: the local TCP(tumor control rate) was 92. 3% (48/52), the disappeared rate was 88. 5% (46/52), one survial year rate 63. 5% (33/52); CFR: TCP was 64. 9%, the disappeared rate was 64. 9% (37/57 ), one survial year rate 42. l% (24/57 ). (SRT vs. CFR, P < 0. 01 ). Conclusion SRT is able to improve local TCP and the disappeared rate, and shorten radiation course of treatment.