摘要
目的探索聚乳酸作为软骨组织工程载体材料的可行性。观察4、8、12周后软骨缺损的情况，并对组织切片评分。方法制备了聚乳酸（PLA）多孔泡沫，将吸附骨髓基质细胞的聚乳酸多孔膜植入兔膝关节软骨负重（内髁）和非负重区（外髁）缺损内。结果骨髓基质细胞可以修复关节软骨缺损。结论聚乳酸是适合吸附骨髓基质细胞修复软骨的载体材料。
Objective The foam of polylactic acid was prepared, the bone marrow stromal cells were absorbed by polylactic acid foam.Method We use the polylactic acid－cells complexes to repair the defects of rabbit articular cartilage in weight bearing and non－weight bearing area, to explore feasibility of polylactic acid as carrier materials in tissue engineering. After 4、8、12weeks the repair tissue was evaluated by histologic method.Result Bone marrow stromal cells are able to repair the detect of articular cartilage.Conclusion The polylactic acid are fit carrier material for bone marrow stromal cell repair the detect of articular cartilage.
出处
《中国组织工程研究》
CAS
CSCD
2001年第10期42-57,共2页
Chinese Journal of Tissue Engineering Research
关键词
聚乳酸
泡沫
骨髓基质细胞
软骨
组织工程
polylactic acid
foam
bone marrow stromal cell
cartilage
tissue engineering
