纳洛酮对急性颈髓损伤后血浆及脑脊液中内皮素、降钙素基因相关肽含量的影响

Effect of naloxone on levels of endothlin－1(ET－1)and alcitonin gene－related peptide(CGRP)in the plasma and cerebrospinal fluid (CSF)after acute cervical spinal cord injury

目的探讨急性颈髓损伤后，纳洛酮对内皮素(ET－1)、降钙素基因相关肽(CGRP)含量的影响。方法用RIA法测定急性颈髓损伤病人血浆及脑脊液中ET－1、CGRP含量，观察纳洛酮对ET－1、CGRP水平及颈髓损伤的影响。结果急性颈髓损伤后血浆及脑脊液ET－1明显升高，CGRP明显下降，经纳洛酮治疗组ET－1较创伤组明显下降，而CGRP明显升高。结论急性颈髓损伤后神经元坏死可能与ET－1水平升高，CGRP明显下降有关，纳洛酮可通过降低ET－1水平、提高CGRP水平而发挥对脊髓神经元的保护作用。

Objective The levels of endothelin－1(ET－1)and calcitonin gene－related peptide(CGRP)in the plasma and cerebrospinal fluid(CSF)after acute cervical spinal cord injury .Method ET－1 and CGRP were determined by RIA in order to observe the effects of naloxone on levels of ET－1 and CGRP and neuronal death of cervical spinal cord.Result Levels of ET－1 in the plasma and cerebrospinal fluid(CSF)after acute cerical spinal cord injury increased significantly;but the levels of CGRP in the plasma and cerebrospinal fluid(CSF) decreased markedly.The levels of ET－1 in the plasma and cerebropinal fluid(CSF)decreased markedly after the threapy of naloxone;but levels of CGRP in the plama and cerebrospinal fluid(CSF)increased sinificantly.Conclusion These deta suggest that the lessening of CGRP and increasing og ET－1 may be some important reson causing death of neuron after acute cervical spinal cord injury,and naloxone can protecet cervical spinal cord neuron by increasing levels of CGRP and decreasing levels of ET－1.