脑脊液浆细胞检查对CNS感染诊断价值初步探讨

A Preliminary Study on CSF Plasmocytes for Diagnosis of CNS Infections

对80例四类中枢神经系统(CNS)感染病人之脑脊液(CSF)中浆细胞计数结果进行了对比分析。该80例病患中,计脑囊虫病(CC)13例,结核性脑膜炎(TBM)23例,病毒性脑膜炎(VM)19例,以及化脓性脑膜炎(PM)25例。浆细胞由B淋巴细胞分化而来,亦称抗体形成细胞(AFC)。各CSF标本中,凡发现有浆细胞者均定为阳性。CC病例组与其他三组相比,CSF的浆细胞阳性率和CSF白细胞中的浆细胞％构成(X)均显著为高;具有最高％构成的一例达31％(可是,其CSF嗜酸性粒细胞％构成仅3％)。至于TBM病例组,仅CSF浆细胞阳性率明显高于VM组和PM组者,其CSF白细胞中的浆细胞％构成(X)与VM组(PM组)者之差异均不显著。从80名病例中随机选出的12个CSF浆细胞阳性标本,它们各各的白细胞中浆细胞％构成与嗜中性粒细胞％构成之间尚无明显的负相关(r=-0.479)。

Comparative analysis was made upon plasmocyte counts in cerebro- spinal fluid (CSF)of 80 patients with central nervous system (CNS) infections,including 13 cerebral cysticercosis (CCC),23 tuberculous meningitis(TSM),19 viral meningitis(VM),and 25 purulent meningitis (PM).Samples with plasmocytes were defined as plasmocyte positive. For CC cases(comparing with the other three groups),both the plas- mocyte positive rate and the mean of distribution percentages(DP)of plasmocytes in CSF leukocytes were remarkably higher,the highest DP being 31％(together with an eosinophils DP of only 3％).For TBM ca- ses,only the plasmocyte positive rate in CSF was obviously higher than those of VM and PM;as for the mean DP of Dlasmocytes in CSF leukoc- ytes,there was no significant difference between TBM and VM/PM.In 12 samples randomized from plasmocyte positive ones,no definite negat- ive-correlation was found between CSF plasmocytes and neutrophils(r= —0.479).