摘要
肠道微生物参与营养吸收、物质代谢、肠道免疫调节等重要的生理过程,并与多种疾病的发生有关系。作为一种必需氨基酸,色氨酸及其微生物代谢产物包括吲哚和吲哚酸衍生物等在维持肠道稳态方面发挥着重要的作用。芳香烃受体(AhR)通过结合其配体(色氨酸微生物代谢产物)调节肠道免疫,有助于维持肠道免疫平衡。本综述主要阐述色氨酸微生物代谢产物发挥维持肠道免疫平衡、维护肠道健康作用的机制,以期为外源色氨酸预防或治疗肠道炎症反应提供新思路。
The intestinal microbiota plays a crucial role in nutrition up-take,component metabolism,as well as intestinal immune modulation.As an essential amino acid,tryptophan and its microbiota metabolites,such as indole and indolic acid derivatives play an important role in the balance between intestinal immune tolerance and intestinal microbiota maintenance.The aryl hydrocarbon receptor(AhR) mediates the modulation of intestinal immune by tryptophan microbiota metabolites(as ligands of AhR),which is beneficial for immune homeostasis.This article mainly clarified the mechanism of intestinal microbiota metabolites regulating the intestinal immune balance and maintaining intestinal health,which provided a new insight on how tryptophan as a nutritional supplementation to prevent or alleviate intestinal inflammation.
作者
邱月琴
杨雪芬
王丽
蒋宗勇
QIU Yueqin;YANG Xuefen;WANG Li;JIANG Zongyong(Institute of Animal Science,Guangdong Academy of Agricultural Sciences,State Key Laboratory of Livestock and Poultry Breeding,Key Laboratory of Animal Nutrition and Feed Science of Ministry of Agriculture in South China,Guangdong Key Laboratory of Animal Breeding and Nutrition,Guangdong Public Laboratory of Animal Breeding and Nutrition,Guangzhou 510640,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2019年第1期42-47,共6页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家重点研发计划(2018YFD0500400
2018YFD0501100)
广州市科技计划项目(201607020035)
国家自然科学基金(31402086)
现代农业产业技术体系建设专项资金(CARS-35)
