长链非编码RNA在恶性血液病发病中的作用研究进展

Research Progress on Long Non-Coding RNA in Hematological Malignancies

长链非编码RNA(long noncoding RNA,LncRNA)是一类长度大于200个核苷酸,不具备编码蛋白质功能的转录片段。以往认为LncRNA在基因结构中并无明显生物学作用,但近年来发现LncRNA能通过调控编码基因的表达而参与机体的作用,LnCRNA也能参与恶性肿瘤的发生、发展、转移及预后过程。随着对肿瘤发生发展机制的深入研究,LnCRNA与肿瘤的关系越来越成为研究的热点。最近关于LncRNA与恶性血液病,如白血病、淋巴瘤、多发性骨髓瘤的关系的研究也日益增多,本文就LncRNA与恶性血液病的关系及其研究进展作一综述。

Long non-coding RNA(LncRNA) is defined as a class of transcripts more than 200 nucleotides in length and without the protein-coding function.It has been found for years,however,that little is known about the potential role of LncRNA in humans.But recent studies showed that LncRNA can regulate the coding-gene expression and participate in effects of human body.Accumulating evidence demonstrated that LncRNA are involved in cancer incidence,development and progression.With further exploration on the mechanisms of tumors,the relationship between the long noncoding RNA and hematological malignancies increasingly become a hot research.This review focuses on the mechanisms of LncRNA in hematological malignancies.