慢性髓系白血病急性转化的机制之一:表观遗传学异常

One of the Mechanisms in Elastic Transformation of Chronic Myeloid Leukemia:Epigenetics Abnormality

慢性髓系白血病是一种起源于骨髓多能造血干细胞的恶性克隆增殖性疾病,其病程进展可分为慢性期、加速期及急变期。导致慢性髓系白血病急性转化的分子机制之一是表观遗传学异常包括DNA修饰、组蛋白修饰及RNA相关调控异常三种分子机制。本文对表观遗传学在CML急性转化过程中的作用做一综述。

Chronic myeloid leukemia is a myeloproliferative disorder characterized by excessive cloning of bone marrow multipotent stem cells.According to the disease course,the CML may be divided into chronic phase(CP),accelerated phase(AP) and blastic phase(BP).At present,the molecular mechanisms of acute transformation of CML has not been fully understood.The recent studies have shown that the epigenetics is one of mechanisms in blastic transformation of CML,including three molecular mechanisms such as DNA modification,histone modifications and RNA-related dysregulation.The molecular mechanisms for epigenetics leading to the transformation of CML are discussed in this review.