淋巴瘤治疗相关乙型肝炎病毒再激活研究进展

Therapy related Virus Reactivation in Lymphoma Patients with Hepatitis B Virus Infection

淋巴瘤患者的乙型肝炎病毒(HBV)感染率远高于正常人群,其治疗相关的HBV再激活是常见的并发症之一,严重者可导致肝功能衰竭而死亡。年龄、性别、HBV感染状态、HBV基因型与基因突变、抗肿瘤药物等多种因素均与之有关。有必要对淋巴瘤合并HBV感染患者在治疗中加强监测,防治HBV再激活。本文就淋巴瘤与HBV感染的流行病学以及HBV再激活的危险因素、发病率、发病机制、临床表现、防治建议作一综述。

The incidence of HBV infection in lymphoma patients is much higher than that in the general normal population.HBV reactivation caused by treatment is one of the common complications in considerable amount of lymphoma patients,which can induce fatal fulminating hepatitis in severe cases.The HBV reactivation in lymphoma patients is related to multiple factors,such as age,sex,HBV infectious state,HBV genotypes and gene mutations,and antitumor drugs.It's necessary to strengthen monitoring prevention and treatment to HBV reactivation in the process of dealing with lymphoma.This review focuses on the epidemiological characteristics of lymphoma and HBV,as well as the risk factors,morbidity,pathogenesis,clinical feature,suggestion on prevention and treatment of HBV reactivation.