多发性骨髓瘤骨病治疗研究进展

Research Advances on Treatment of Multiple Myeloma Bone Disease

多发性骨髓瘤骨病(multiple myeloma bone disease,MBD)以破骨细胞(osteoclast OC)活性增强及成骨细胞(osteoblast,OB)功能受抑制致广泛骨质溶解为特征,临床表现为骨痛、骨质疏松、病理性骨折以及相关神经压迫症状等。MBD是多发性骨髓瘤(Multiple Myeloma,MM)最常见的并发症之一,严重影响患者的生存质量,与疾病的预后密切相关,但其发病隐匿,误诊率较高,临床上患者的生存质量及预后较差。本文通过对其发病机制及最新治疗进展进行综述,为临床治疗MBD提供参考。

The main features of multiple myeloma bone disease(MBD) are hyperactivity of systemic bone destruction and inhibition of new bone formation.Its clinical manifestations include pain,osteoporosis,pathologic fractures and associated nerve compression symptoms etc.MBD is one of the most common complications of multiple myeloma(MM).Its misdiagnosis rate is higher,and the patients' quality of life and prognosis are poor.This review discusses the most recent advancement on its pathogenesis and novel therapies,so as to provide reference for clinical treatment of MBD.