46例老年外周T细胞淋巴瘤的临床特点和预后分析

Analysis of Clinical Characteristics and Prognosis of 46 Elderly Patients with Peripheral T Cell Lymphoma(PTCL)

目的:探讨老年外周T细胞淋巴瘤(Peripheral T-cell lymphoma,PTCL)的临床特点和预后因素。方法:回顾性分析2008年4月至2014年8月天津医科大学肿瘤医院46例老年外周T细胞淋巴瘤患者的临床资料,包括临床特征、预后因素及治疗等;对46例均进行了随访,中位随访时间为11个月(2-64个月)。采用Kaplan-Meier方法进行生存分析,应用COX比例风险模型进行多因素分析。结果:中位生存时间(OS)为11个月,预期1、2、3年生存率分别为50%、36%、33%。单因素分析显示,年龄、ECOG评分、查尔森合并症指数(Charlson Comorbidity Index,CCI)评分、化疗疗程数、疗效是影响老年PTCL患者OS和PFS的相关因素。多因素分析显示,ECOG评分及疗程数则均是影响患者OS和PFS的独立预后指标(P<0.05)。结论:ECOG评分及疗程数对于预测老年PTCL患者预后具有重要意义。对老年淋巴瘤患者的治疗要充分考虑患者的一般状况,同时要完成一定强度的化疗,是改善老年患者生存的重要措施。

Objective:To investigate the clinical characteristics and prognostic factors of patients with peripheral T cell lymphoma(PTCL).Methods:The clinical data of 46 elderly PTCL patients admitted in Tianjin Medical University Cancer Hospital from April 2008 to August 2014 were collected,the clinical features,prognostic factors and treatments,as well as followed-up outcome were analyzed retrospectively.Survival analysis was performed by Kaplan-Meier method,and the COX proportional hazard model was used to perform multivariate analysis.Results:The median survival time was 11 months,and the expected 1- year,2- year and 3- year overall survival rate(OS) was 50%,36%and 33%,respectively.Univariate analysis showed that the age,ECOG score,Charlson Comorbidity Index Score,the efficacy and course of chemotherapy were all the prognostic indicators affecting the OS and progression free survival(PFS) in this cohort of elderly patients.Multivariate analysis indicated that ECOG score and course of chemotherapy were the independent prognostic indicators affecting the OS and PFS(P <0.05).Conclusion:ECOG score and course of chemotherapy are of great significance for predicting the prognosis in elderly PTCL patients.The elderly patients ’s general condition and completion of a certain intensity of chemotherapy are an important measure to prolong survival time in elderly PTCL patients.