染色质重塑因子BRG1在急性髓细胞白血病中作用的研究进展

Research Progress on the Role of Chromatin Remodeling Factor BRG1 in Acute Myeloid Leukemia ——Review

BRG1(Brahma-related gene 1,BRG1)是染色质重塑复合体SWI/SNF中的重要的ATP酶亚基,其在细胞周期调控、DNA修复以及肿瘤发展中发挥重要作用。不同于以往作为抑癌基因的证据,最新的研究结果发现在急性髓细胞白血病(Acute myeloid leukemia,AML)中BRG1对于白血病细胞的生长维持起重要作用,并且这种作用对于正常造血干细胞是非必需的。深入研究BRG1在急性髓细胞白血病中的作用及机制,将有助于开发非常有潜力的靶向治疗策略。本文就BRG1在AML白血病细胞及白血病干细胞中的作用及相关机制做一综述,为AML靶向治疗策略的研究提供参考。

BRG1( Brahma-related gene 1,BRG1) is the ATPase subunit of SWI / SNF chromatin remodeling complexes,w hich plays an important role in cell cycle regulation,DNA repair and tumor development. Unlike the evidence as tumor suppressor genes in the past reports,latest researches show that BRG1 plays an important role in sustaining the grow th of leukemia cells in acute myeloid leukemia,and these effects on normal hematopoietic stem cells are dispensable. Further studies of the role and mechanism of BRG1 in acute myeloid leukemia w ill contribute to the development of a new and promising targeted therapy strategy. This article review s the role of BRG1 on leukemia cells and leukemia stem cells in AM L and discusses the related mechanism,w hich providing some reference for the targeted treatment strategy of AM L.