内皮细胞损伤在急性移植物抗宿主病的研究进展

Research Progress on Endothelial-Cell Injury in the Acute Graft-Versus-Host Disease——Review

目前,越来越多的证据表明移植物抗宿主病(GVHD)中存在着免疫介导的内皮损伤。内皮细胞是GVHD过程中免疫攻击的一重要靶点,且血管内皮损伤是a GVHD发生的早期事件,其损伤标志物可能成为诊断a GVHD的指标。内皮细胞在不同的组织器官中表型的差异导致组织器官GVHD的发生亦有差异。虽然大量研究表明,内皮细胞在a GVHD的发生过程中有着重要作用,但是其在allo-HSCT中的具体作用机制仍不明确。本文就a GVHD中内皮细胞的损伤及其生物学标志研究进展做一综述,为临床GVHD的预防和治疗提供相应的策略和靶点。

Recently there are increasing evidence of the existence of an immune-mediated endothelial-cell injury in the acute graft-versus-host disease( a GVHD). Endothelial cells are an important target in the process of GVHD immune attacking,and vascular end thelial injure is an early event of tissue injury caused by a GVHD after allogeneic hematopoietic stem cell transplantation( allo-HSCT). Biomarkers for endothelial damage w ere consisted w ith endothelia injury,w hich may be considered a valuable marker to confirm GVHD diagnosis. The endothelial cell phenotype differs betw een organs,w hich results in organ-dependent differences for the involved organs w hen GVHD occurring. Although the endothelial cells play an impartant tole in process of a GVHD occurence,a further research to better characterize its role in allo-HSCT is needed. This review focusses on the research progress of a GVHD after allo-HSCT and endothelial-cell injury,as w ell as is markers so as to provide corresponding strategies and targets for the prevent and treatment of a GVHD.