皮肤淋巴组织瘤样增生(CLH)32例临床病理分析

A Retrospective Clinicopathologic Study of 32 cases of Cutaneous Lymphoid Hyperplasia(CLH)

目的总结CLH的临床病理特点,以减少误诊。方法选取CLH病例32例,分为三组进行回顾性病例分析。第1组:单部位病例,具有"特征性的"肉眼及临床特点;第二组:单部位病例,但无以上特点;第3组:多部位病例。结果 1.第一组病例除具有"特征性的"肉眼及临床特点外,亦具有特征性的镜下特点。第三组病例病史较为复杂。2.三组病例镜下形态及免疫形态的共同点:表皮及皮肤附属器无破坏;病变细胞种类杂,除T、B细胞外混杂组织细胞、浆细胞、CD30阳性的活化大细胞;Ki-67大部分病例可达到20-40%。3第一、二组病例以T-CLH居多,第三组病例全部为B-CLH病例。

Objective To elucidate the clinical and pathological characteristic of CLH,in order to reduce the misdiagnosis.Methods 32 patients diagnosed CLH were retrospectively analyzed.They were divided into 3 groups,Group one is single-location case with distinctive medical history.Group two is single-location without distinctive medical history.Group three is multiple-location case.Results The CLH has some clinical and pathological characteristics,and it can be identified from Cutaneous lymphoma.The patients in first group not only have a distinctive medical history but also have microscopic characteristics.The patients in third group have the most complicated history.Cases in group one and two mostly are T-CLH.While group three totally are bolo-B-CLH.