他汀治疗≥80岁的高脂血症患者的疗效及安全性观察

The Study of Clinical Efficacy and Safety of Statinsin Treatment of Patients at Age of 80 Years or Elder

目的探讨≥80岁患者应用他汀降脂的效果和安全性。方法选择我院≥80岁的血脂异常患者96人,随机分配为阿托伐他汀组(50人)及辛伐他汀组(46人)治疗1年。观察指标有肝肾功能、血脂等指标。结果辛伐他汀组总有效率为85.12%,阿托伐他汀组总有效率为95.15%,两组间比较有统计学差异(P<0.05)。两组治疗前后比较总胆固醇(CHO)、甘油三酯(TG)及低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),差异均有统计学意义(P<0.05)。而谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)、肌酐(Cr)、空腹血糖(GLU),差异无统计学意义(P>0.05)。结论他汀用于≥80岁的患者安全有效,阿托伐他汀具有更好的安全性优势。

Objective:Discusses the application of 80 year old patients or higher statin lipid-lowering effect and safety.Methods Choose our 80 year old patients with dyslipidemia or 96 people,randomly assigned for atorvastatin group(50)and simvastatin group(46)treatment for 1 year.Observation indexes such as liver and kidney function,blood lipids index.Results Simvastatin group total effective rate was 85.12%,atorvastatin group total effective rate was 95.15%,the comparison between the two groups was statistically difference(P<0.05).In the two groups before and after treatment comparison of total cholesterol(CHO),triglycerides(TG)and low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),the difference had statistical significance(P<0.05).And alanine aminotransferase(ALT),aspertate aminotransferase(AST),creatine kinase(CK),creatinine(Cr),fasting plasma glucose(GLU),there was no statistically significant difference(P>0.05).Conclusion Statins for patients,a 80 year old is safe and effective,or atorvastatin has better security advantages.