诺通与肾上腺素在鼻腔、鼻窦手术中应用的比较

Comparation of xylonmetazoline hydrochloride and adrenaline in application of nasal cavity and sinus surgery

目的探讨诺通与肾上腺素在鼻腔、鼻窦手术中的应用价值。方法分别观察诺通组、肾上腺素组患者在鼻腔、鼻内窥镜手术中5分钟、10分钟、30分钟时血压、心率的变化,观察出现反跳性鼻腔黏膜充血肿胀的时间和例数,计算出血量并记录。结果诺通组手术前后,30例患者的血压、心率变化差异无显著性,1例局麻患者出现了不良的心血管反应。肾上腺素组手术前后,30例患者的血压、心率变化差异无显著性,3例局麻患者出现了不良的心血管反应。诺通组无1例出现反跳性鼻腔黏膜充血肿胀,肾上腺素组有6例出现轻微的反跳性鼻腔黏膜充血肿胀,诺通组平均出血量300mL,肾上腺素组平均出血量280ml,(P>0.05)。结论我们认为鼻腔、鼻窦手术中,在鼻腔黏膜收缩,血压、心率的改变及出血量方面,诺通组肾上腺素组无明显差异。且使用诺通与肾上腺素相比较,术中间监测血压,心率变化幅度更小,且无鼻腔黏膜反射性充血肿胀。故诺通作为鼻腔、鼻窦手术的减充血剂是更安全、有效的。

Objective To explore the value of xylonmetazoline hydrochloride and adrenaline in application of nasal cavity and sinus surgery.Method To observe the change of the blood pressure and heart rat of xylonmetazoline hydrochloride group and adrenaline group on repeatively,at 5,10,30min and cases of nasal mucosa rebound swelling,and to conduct average bleeding.Results No significant difference was shown in 30 cases in their blood pressure and heart rat before and after xylonmetazoline hydrochloride application,the same as to adrenalin group.1 case adverse cardiovascular reactions in xylonmetazoline hydrochloride group,6 cases adverse cardiovascular reactions in adrenalin group.No cases were found rebound nasal mucosa swelling in xylonmetazoline hydrochloride group,mild response was observed in 6 cases of adrenalin group.The average bleeding was 305ml in xylonmetazoline hydrochloride group well as 280ml in adrenalin group,P>0.05.Conclusion There were no significant differences between the two groups.xylonmetazoline hydrochloride group is safer and effectiver than adrenalin group as nasal mucosa decogestant.