儿童过敏性紫癜早期肾损害的实验室检查指标选择及临床意义

The choice and clinical significance of laboratory index of early renal damage of anaphylactoid purpura in childhood

目的探讨过敏性紫癜患儿早期肾损害诊断的实验室检查指标及临床意义。方法随机选择2010年1月至2013年1月我院收治的60例尿常规检查结果正常的过敏性紫癜患儿(设为A组)和同期收治的60例尿常规检查结果异常的过敏性紫癜患儿(设为B组)作为观察对象,另选择同期尿常规检查结果正常的60例非肾脏疾病患儿作为对照组,进行尿微量蛋白、尿酶、肾功能等相关指标检测,并进行对比。结果 A组与B组间尿微量蛋白、尿酶的比较有显著性差异(P<0.05),对照组与A组、B组间尿微量蛋白、尿酶的比较亦有显著性差异(P<0.05)。同时,过敏性紫癜患儿尿微量蛋白、尿酶与肾功能检查的阳性率比较存在显著性差异(P<0.05)。结论对过敏性紫癜患儿进行尿微量蛋白与尿酶检查,有利于该疾病早期肾损害的诊断与治疗,只有随时把握患儿的尿酶与尿微量蛋白相关指标变化情况,才能早期积极有效的进行干预治疗,更有效保证患儿治疗质量。

Objective To investigate the choice and clinical significance of laboratory index of early renal damage of anaphylactoidpurpura in childhood.Methods A total of 60patients with anaphylactoid purpura and normal urine test from January of 2010to January of 2013were taken as A group,and120cases with abnormal urine test were taken as B group,and 60cases with the non-kidney disease and normal urine testwere taken as control group.To test and contrast u-albumin,urine enzyme and renal function.Results The differences of u-albumin and urine enzyme of A and B group had statistically significant(P<0.05),the differences of u-albumin and urine enzyme of control group,A group and B group had statistically significant(P<0.05).The positive rate of u-albumin,urine enzyme and renal function of anaphylactoid purpura had statistically significant(P<0.05).ConclusionFor children with allergic purpura,urine enzyme and u-albumin test is conducive to the early diagnosis and treatment of renal damage of this disease.Grasping the changes of urine enzyme and u-albumin,and taking positive and effective early intervention treatment can ensure the quality of treatment more effectively.