木丹颗粒联合甲钴胺、α-硫辛酸治疗糖尿病周围神经病变的疗效观察

Effect of Mudan granule combined with methylcobalamin,alpha lipoic acid in the treatment of diabetic peripheral neuropathy observation

目的观察木丹颗粒联合甲钴胺、α-硫辛酸治疗糖尿病周围神经病变(DNP)的临床疗效。方法将52例DNP患者随机分为观察组和对照组,在运动、饮食、糖尿病教育及血糖、血压、血脂得到有效控制基础治疗之上,观察组用木丹颗粒联合甲钴胺、α-硫辛酸治疗,对照组用甲钴胺、α-硫辛酸治疗,疗程2周。观察治疗前后的症状改善情况,测定优势侧神经传导速度。结果⑴组间有效、显效、无效率比较差异有统计意义(P<0.05),观察组疗效显著。⑵自身前后对照:两组神经传导速度均有改善,以观察组改善更显著。结论木丹颗粒联合甲钴胺、α-硫辛酸治疗糖尿病周围神经病变疗效确切,优于甲钴胺、α-硫辛酸方案。

Objective To observe the Mudan granule combined with methylcobalamin,alpha lipoic acid in the treatment of diabetic peripheral neuropathy(DNP)clinical curative effect.Methods 52patients with DNP were randomly divided into observation group and control group,effectively control therapy in the exercise,diet,education of diabetes andblood glucose,blood pressure,blood lipid,use of Mudan granule combined with methylcobalamin,alpha lipoic acid in the observation group,the control group with methylcobalamin,alpha lipoic acid treatment,2weeks treatment.Observed before and after treatment of the symptoms to improve the situation,determination of lateral nerve conduction velocity advantage.Results there are statistical significance between group markedly effective,effective1,no efficiency difference(P<0.05),the observation group effect.The self control:two groups of nerve conduction velocity were improved,the observation group improved more significantly.Conclusion the effect of peripheral nervelesions of Mudan granule combined with methylcobalamin,alpha lipoic acid in the treatment of diabetes is exact,better than Mecobalamin,alpha lipoic acid.