高碘与高氟联合慢性暴露对8～10岁儿童甲状腺功能的影响

The influence of thyroid function of 8～10 years old children by chronic exposure of high iodine combine high fluoride

目的探讨高碘与高氟联合慢性暴露对8~10岁儿童甲状腺功能的影响。方法选取本地出生的8~10岁儿童48例,根据不同地区水碘平均浓度和水氟平均浓度分为高氟组17例、高碘高氟组11例、对照组20例。对所有儿童儿童尿氟、尿碘水平。结果高氟组与高碘高氟组的尿碘、尿氟水平均高于对照组,差异有统计学意义(P<0.05);高氟组SOD水平、ROS水平与高碘高氟组、对照组比较,差异有统计学意义(P<0.05)。结论高碘与高氟联合慢性暴露会对儿童甲状腺功能造成较大影响,甲状腺水平中除T4外无显著差异,SOD和ROS可作为高氟高碘损害的有效标志物。

Objective To discussed the influence of thyroid function of 8~10years old children by chronic exposure of high iodine combine high fluoride.Methods Select the locally born children 8~10years old in 48 cases,according to the average concentration of iodine in different parts of the water and the average concentration of fluoride in drinking water is divided into 17 cases of high fluoride group,11 cases of high iodine high fluoride group and the control group of 20 patients.Children of all urinary fluoride,urinary iodine levels.Results Fluoride Fluoride group and high iodine group urinary iodine,urinary fluoride levels were higher,the difference was statistically significant(P<0.05);high fluoride levels of SOD,ROS high fluoride levels and high iodine group and the control group,the difference was statistically significant(P<0.05).Conclusion That will caused large influence of children by chronic exposure of high iodine combine high fluoride,there is no significant difference excepted T4 in the thyroid levels,the SOD and ROS able to be the effective marker of the damage by high fluoride and high iodine.