糖尿病颈动脉粥样硬化患者内皮祖细胞变化特点

Characteristics of Endothelial Progenitor Cells in Patients with Diabetic Carotid Atherosclerosis

目的探讨2型糖尿病与糖尿病颈动脉粥样硬化患者内皮祖细胞(EPCs)的数量变化及特点。方法 32例健康成年人为对照组,104例确诊糖尿病患者,将其通过多普勒超声测量颈动脉分为单纯糖尿病组(DM)56例和糖尿病粥样硬化组48例,采集受试者血压、血糖、胰岛素、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、极低密度脂蛋白(VLDL-C)等临床指标,采集糖尿病粥样硬化组的颈动脉内膜中层厚度(IMT),并测试三组的内皮祖细胞(EPCs)进行分析对比。结果糖尿病颈动脉硬化组的EPCs、HOMA胰岛素抵抗指数均高于DM组和对照组,且EPCs与IMT、HOMA胰岛素抵抗负相关关系。结论糖尿病早期即对内皮功能有所影响,胰岛素抵抗是影响内皮功能的重要因素。

Objective to explore the number's differences and characteristics of endothelial progenitorcells(EPCs)of type 2 diabetes patients and diabetic patients with carotid atherosclerosis. Methods 32 healthy adults is a control group.104 patients diagnosed with diabetes,divided into DM group(56 examples)and diabetes with carotid atherosclerosis group(48 samples)divided by Doppler ultrasoundto measure. Blood samples are collected,glucose,insulin,triglycerides(TG),total cholesterol(TC),high densitylipoprotein(HDL-C),low densitylipoprotein(LDL-C),very low densitylipoprotein(VLDL-C)and so on. collected carotidintima-media thickness(IMT),and tested three group sofendothelial progenitorcells(EPCs)collected in diabetes with atherosclerosis group are analysised and comparisoned. Results EPC scarotid atherosclerosisin diabeticgroup,HOMAinsulin resistance indexwere higher than DMgroup and control group,EPCsand IMT,HOMAinsulin resistancenegative correlation. Conclusion diabetes have an impact on endothelial function early,insulin resistanceis an important factoraffectingendothelial function.