偏头痛合并卵圆孔未闭的发病及其机制研究进展

Disease and Mechanism of Migraine Combined with Patent Foramen Ovale

偏头痛是一种常见的神经系统疾病,而卵圆孔未闭(PFO)被认为与偏头痛的发病相关。研究表明,PFO更多的与先兆性偏头痛相关性紧密,主要认为是化学物质触发机制诱导偏头痛的产生。文章介绍了PFO主要诊断研究进展,而经食道超声心动图声学造影或经颅多普勒超声声学造影为目前临床首选。对偏头痛合并卵圆孔未闭的发病关系以及相关机制进行论述,为临床治疗偏头痛患者及偏头痛合并卵圆孔未闭的发病提供理论依据。

Migraine is a common neurological disorder,and patent foramen ovale(PFO)is considered to have a role in migraine. The relationship between migraine and PFO may be stronger in patients suffering from migraine with aura(MA). More research shows that PFO more closely correlation with MA and mainly considered a chemical trigger mechanism to induce migraine. This paper introduces the research progress of PFO diagnosis,the contrast transesophageal echocardiography(c-TEE)and contrast transcranial doppler ultrasonagraphy(c-TCD)for clinical choice at present. Discussed the relationship and possible mechanism of migraine combined with PFO,provided more theories for the clinical treatment of migraine patients and migraines combined with PFO.