奥拉西坦联合尼莫地平治疗血管性痴呆的疗效及安全性

Efficacy and Safety of Combination Therapy of Oxiracetam and Nimodipine in the Treatment of Vascular Dementia

目的探讨奥拉西坦联合尼莫地平治疗血管性痴呆的有效性及安全性。方法对照组在常规治疗基础上加用尼莫地平,研究组在常规治疗基础上给予尼莫地平、奥拉西坦。对比两组疗效及不良反应发生情况。结果治疗后研究组MMSE量表评分改善效果优于对照组(P<0.05)。结论血管性痴呆患者经奥拉西坦、尼莫地平联合治疗有效性、安全性均较优。

Objective To investigate the efficacy and safety of oxiracetam and nimodipine in the treatment of vascular dementia. Methods The control group was treated with nimodipine on the basis of conventional therapy. The study group was given nimodipine and oxazetam on the basis of routine therapy.Efficacy and safety were compared between groups. Results The score of MMSE was better than that of the control group(P<0.05). Conclusions Patients with vascular dementia were treated with oxorazetam and nimodipine in combination with superior efficacy and safety.