丁苯酞胶囊联合依达拉奉治疗脑梗死的疗效观察

Clinical Observation of Butylphthalide Capsule Combined with Edaravone in Treating Cerebral Infarction

目的评估丁苯酞联合依达拉奉治疗急性脑梗死疗效及安全性。方法回顾性研究急性脑梗死120例,随机分为对照组(依达拉奉组)和联合组(丁苯酞胶囊与依达拉奉组)。记录观察两组治疗前、治疗后7、14天神经功能缺损评分(NISS评分),以及治疗7、14天后行Barthel(日常生活能力)评分。并观察药物不良反应。结果治疗前,两组NISS评分无明显统计学差异,联合组治疗后NISS评分明显低于对照组(P<0.05)。两组治疗前Barthel评分无明显统计学差异,联合组治疗后Barthel评分明显高于对照组(P<0.05)。2组不良反应差异无统计学意义。结论丁苯酞胶囊联合依达拉奉疗效显著,安全性高,能明显改善脑梗死患者神经功能及日常生活能力。

Objective To evaluate the efficacy and safety of butylphthalide combined with edaravone in the treatment of acute cerebral infarction.Methods A retrospective study of 120 patients with acute cerebral infarction was conducted,patients were divided into control group(edaravone group)and combination group(butylphthalide capsule and edaravone group).The neurological deficit scores(NISS scores)of the two groups before treatment,7 and 14 days after treatment,and Barthel(daily living ability)score after 7 and 14 days of treatment were observed.The adverse drug reactions were observe.Results Before treatment,there was no significant difference in NISS scores between the two groups.NISS scores in the combined group were significantly lower than those in the control group(P<0.05).There was no significant difference between the two groups before treatment Barthel score,Barthel score was significantly higher in the combined group after treatment than the control group(P<0.05).There was no significant difference in adverse reactions between the two groups.Conclusion Butylphthalide capsule combined with edaravone has significant curative effect and high safety.It can significantly improve the neurological function and daily living ability of patients with cerebral infarction.