幽门螺杆菌与特发性血小板减少性紫癜关系的Meta分析

Meta-Analysis of Relationship between Helicobacter pylori and Idiopathic Thrombocytopenic Purpura

目的探究幽门螺杆菌(HP)与特发性血小板减少性紫癜(ITP)的关系。方法检索Pub Med、EMbase、CNKI等国内外各大数据库于2006—2016年公开发表的有关HP感染和ITP关系相关的研究文献,并采用STATA12.0分析软件对所有纳入文献进行敏感性分析和发表偏倚分析等分析,计算综合的OR值及95%CI。结果共检索到相关文献154篇,经过最终筛选后,确定有效文献11篇,其中英文文献3篇,病例组166例,对照组96例;中文文献8篇,病例组1137例,对照组1116例。对纳入文献进行meta分析,OR=1.80,95%Cl为1.48~2.19,合并效应量的检验结果为Z=5.93,P=0.000。结论 HP感染与ITP的发病密切相关。

Objective To investigate the relationship between Helicobacter pylori(HP)and idiopathic thrombocytopenic purpura(ITP)by systematic analysis.Methods The major domestic and foreign databases(Pub Med,EMbase,CNKI and so on)were searched for randomized controlled trials(RCTs)of the relationship between HP and idiopathic thrombocytopenic purpura published in 2006—2016.STATA12.0 analysis software was used for sensitivity analysis and publication bias analysis,calculating the comprehensive value of OR and 95%CI.Results Totally 154 literatures were retrieved.After the final screening,11 valid documents were identified,including 3 English articles,166 in case group and 96 in control group.There were 8 articles in Chinese literature,1137 cases in the case group and 1116 cases in the control group.Meta-analysis was carried out on the included literatures.The results analyzed were as follows:OR=1.80,95% Cl:1.48~2.19,and the combined effect was z=5.93,P=0.000.Conclusion HP infection is closely related to the incidence of ITP,but the sample size of this study is limited.Further confirmation is needed with a larger sample of research and analysis.