右美托咪定和硝酸甘油在鼻内镜手术中的应用比较

Comparison of Application of Dexmedetomidine and Nitroglycerine in Nasal Endoscopic Surgery

目的探讨右美托咪定和硝酸甘油在鼻内镜手术中的应用效果。方法将78例行鼻内镜手术患者随机分为对照组与实验组,每组39例。实验组采用右美托咪定,对照组应用硝酸甘油。观察对比两组的疗效。结果诱导前5 min实验组和对照组患者的心率和平均动脉压差异无统计学意义(P>0.05)。手术开始后30 min对照组患者平均动脉压及心率均明显高于实验组(P<0.05)。和对照组相比,实验组患者降压速度较快,且实验组患者的术中出血量少于对照组(P<0.05)。结论右美托咪定对鼻内镜手术患者的应用效果较为显著,具有较高的临床价值。

Objective To explore the effect of dexmetomidine and nitroglycerine in nasal endoscopic surgery. Methods Seventy-eight patients were randomly divided into control group and experimental group,with 39 cases in each group. The experimental group was given dexmeidine,and nitroglycerine was used in the control group. Observe and compare the effect of the two groups. Results there was no statistically significant difference between the heart rate and mean arterial pressure(P<0.05)in the patients in the first 5 min in the experiment and control groups. The mean arterial pressure and heart rate were significantly higher in the 30 min in the control group after the surgery(P<0.05). Compared with the control group,the blood pressure in the experimental group was faster,and the intraoperative blood loss in the experimental group was less than that in the control group(P<0.05). Conclusion Dexmeidine has a significant effect on the application of endoscopic surgery and has high clinical value.